血小板相关参数与凝血指标在肝硬化疾病中的应用探讨

Discussion on the application of platelet related parameters and coagulation indexes in liver cirrhosis

目的探讨血小板相关参数与凝血指标在肝硬化和健康人群的差异及应用。方法收集2017年2月~2019年2月在我院就诊的205例肝硬化患者和205例健康体检人员作为研究对象,将健康体检人员作为对照组,肝硬化患者作为观察组,对两组人群进行血小板相关参数和凝血指标的检验,分析这些指标与肝硬化的关系。结果实验组的血小板计数(platelet count,PLT)和血小板比容(platelet crit,PCT)显著低于对照组(P<0.05),观察组的血小板平均体积(mean platelet volume,MPV)和血小板分布宽度(platelet volume distribution width,PDW)显著高于对照组(P<0.05)。实验组的凝血酶原时间(prothrombin time,PT)、凝血酶时间(Thrombin time,TT)和活化部分凝血酶活酶时间(Activated partial thrombin activity time,APTT)均显著长于对照组,观察组的纤维蛋白原明显低于对照组(P<0.05)。结论血小板相关参数与凝血指标在肝硬化诊疗中具有实际的应用效果,根据检验者血液中的血小板相关参数与凝血指标可以比较出肝硬化患者和健康人群在血液检查指标上的差异,从而在临床用药方面、降低出血风险、预后判断提供参考。

Objective To explore the difference and application of platelet related parameters and coagulation indexes in liver cirrhosis and healthy people.Methods 205 patients with liver cirrhosis and 205 healthy people who were treated and physically examined in our hospital from February 2017 to February 2019 were selected as the research subjects.The healthy examinees were taken as the control group and the patients with liver cirrhosis were taken as the observation group.The platelet related parameters and coagulation indexes of the two groups were tested,and the correlation between these indexes and liver cirrhosis was analyzed.Results The platelet count(PLT)and platelet crit(PCT)in the observation group were significantly lower than those in the control group(P<0.05).The mean platelet volume(MPV)and platelet volume distribution width(PDW)in the observation group were significantly higher than those in the control group(P<0.05).The prothrombin time(PT),thrombin time(TT)and activated partial thrombin activity time(APTT)in the observation group were significantly longer than those in the control group,and the fibrinogen in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Platelet related parameters and coagulation indexes have practical application effectiveness in the diagnosis and treatment of liver cirrhosis.The differences in blood indexes between the patients with liver cirrhosis and the healthy people can be concluded through the detection of platelet related parameters and coagulation indexes,so as to provide reference for clinical medication and prognosis judgment,and reduce the risk of bleeding.