中药联合微波消融治疗肝癌的临床观察

Clinical Observation of Chinese Medicine Combined with Microwave Ablation for Liver Cancer

目的研究中药联合微波消融治疗原发性肝癌的近期疗效及安全性。方法选取2016年-2018年广东医科大学附属中山医院肿瘤中心原发性肝癌患者63例,随机分成2组,对照组患者单纯采用微波消融治疗,治疗组在微波消融治疗的基础上联合中药治疗,治疗观察1月,记录治疗前后疾病控制率、甲胎蛋白及异常凝血酶原水平、生活质量评分变化及安全性指标。结果中药联合微波消融治疗组疾病控制率为90%,对照组微波消融组为76.7%,差异具有统计学意义;治疗组的甲胎蛋白(alpha fetoprotein,AFP)及异常凝血酶原(PIVKA II)下降水平较对照组显著(P<0.05);治疗组生活质量改善方面明显高于对照组,差异具有统计学意义;在安全性指标方面,治疗组消化道反应发生率低于对照组;两组肝区疼痛、肝功能异常方面无明显差异(P>0.05)。结论中药联合微波消融治疗肝癌可以提高疾病控制率,显著改善患者生存质量,且安全性良好,中药联合微波消融治疗或可作为临床治疗肝癌安全有效的治疗模式。

Objective To study the short-term efficacy and safety of Chinese medicine combined with microwave ablation in the treatment of primary liver cancer.Methods Sixty-three patients with primary liver cancer admitted in Zhongshan Hospital Affiliated to Guangdong Medical University from 2016 to 2018 were randomly divided into two groups.The control group was treated with microwave ablation alone,and the treatment group was treated with Chinese medicine on the basis of microwave ablation treatment.The treatment lasted for one month.Before and after treatment,the disease control rate,the levels of alpha fetoprotein(AFP)and abnormal prothrombin PIVKA II,and the changes in the scores of quality of life and safety indicators were recorded in the two groups.Results The disease control rate in the treatment group was 90.0%,and that in the control group was 76.7%,and the difference between the two groups was statistically significant(P<0.05).The treatment group had stronger effect on decreasing the levels of AFP and prothrombin PIVKA II,and on improving the quality of life of the patients than the control group(P<0.05).In terms of safety indicators,the incidence of gastrointestinal reactions in the treatment group was lower than that in the control group,but the differences of hepatalgia and abnormal hepatic function indicators between the two groups were not statistically significant(P<0.05).Conclusion Chinese medicine combined with microwave ablation can enhance the disease control rate,significantly improve the quality of life of patients,and has good safety,indicating that the combined therapy will be a safe and effective treatment method for the treatment of liver cancer.