中医综合干预方案对早期先兆流产患者妊娠结局的影响

Effect of comprehensive intervention program of traditional Chinese medicine on pregnancy outcome of patients with early threatened abortion

目的观察中医综合干预方案对先兆流产患者妊娠结局的影响。方法将110例先兆流产患者按照随机数字表法分为2组。对照组55例予西医常规治疗;治疗组55例在对照组治疗基础上加用中医综合干预方案(中药口服、穴位贴敷及足浴)。2组均连续治疗2周。比较2组疗效;观察2组治疗前后中医证候积分变化;比较2组出血持续时间及妊娠结局(分娩成功率及分娩孕周)。结果治疗组总有效率89.09%,对照组总有效率72.73%,治疗组疗效优于对照组(P<0.05)。2组治疗后中医证候主症积分、次症积分及总积分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组出血持续时间≤5 d、6~9 d的患者所占比例均高于对照组(P<0.05),出血持续时间≥10 d的患者所占比例低于对照组(P<0.05)。治疗组分娩成功率(85.45%)高于对照组(69.09%,P<0.05);2组分娩孕周比较差异无统计学意义(P>0.05)。结论在西医常规治疗基础上联合中医综合干预方案治疗先兆流产,可改善临床症状,减少阴道出血,有效提高临床疗效及患者分娩成功率。

Objective To observe the effect of comprehensive intervention program of traditional Chinese medicine on pregnancy outcome of patients with early threatened abortion. Methods 110 patients with threatened abortion were divided into two groups according to random number table method. 55 cases in control group were treated by conventional western medicine. 55 cases in treatment group were treated by comprehensive intervention program(oral Chinese medicine, acupoint application and foot bath) on the basis of the control group. Both groups were treated for two weeks. The curative effect of the two groups was compared. The change of TCM syndrome integral before and after the treatment were observed. The bleeding duration and pregnancy outcome(success rate of fetal protection and pregnancy week of delivery) of the two groups were compared. Results The total effective rate was 89.09 % in treatment group and 72.73 % in control group. The clinical curative effect of the treatment group was better than that of the control group(P<0.05). The main syndrome score, secondary syndrome score and total score of the two groups were lower than those of the group before treatment(P<0.05), and the treatment group was significantly lower(P<0.05). The proportion of patients with bleeding duration less than or equal to 5 days and 6 to 9 days in the treatment group was higher than that in the control group(P<0.05), and the proportion of patients with bleeding duration more than or equal to 10 days was lower than that in the control group(P<0.05). The success rate of the treatment group(85.45%) was higher than that of the control group(69.09%, P<0.05). There was no significant difference in gestational weeks between the two groups(P>0.05). Conclusion The combination of conventional western medicine and traditional Chinese medicine can improve the clinical symptoms of threatened abortion, relieve vaginal bleeding, and improve the curative effect of patients and the success rate of fetus protection.