中药穴位贴敷治疗肿瘤患者奥施康定相关性便秘的效果

Effect of acupoint application of traditional Chinese medicine on constipation related to Oxkangding in cancer patients

目的评价中药穴位贴敷治疗肿瘤患者奥施康定相关性便秘的效果。方法选取2017年1月~2019年6月于首都医科大学附属北京中医医院肿瘤科治疗的使用奥施康定出现相关性便秘的肿瘤患者72例。将符合标准的患者按随机数字表法分为治疗组(中药穴位贴敷,36例)和对照组(口服乳果糖,36例)。观察两组便秘的发生率、排便情况、生活质量[卡氏功能状态评分(KPS)]、疼痛[疼痛数字评分法(NRS)]评分。结果两组治疗期间、随访期间便秘发生率比较,差异无统计学意义(P>0.05);治疗组治疗期间与随访期间便秘发生率比较,差异有统计学意义(P<0.05);对照组治疗期间与随访期间便秘发生率比较,差异有统计学意义(P<0.05)。两组排便不尽感、腹胀及排便前腹痛发生率比较,差异有统计学意义(P<0.05);两组便质硬发生率比较,差异无统计学意义(P>0.05)。两组治疗前KPS评分比较,差异无统计学意义(P>0.05);两组治疗后KPS评分比较,差异无统计学意义(P>0.05);两组治疗后KPS评分明显高于治疗前,差异有高度统计学意义(P<0.01)。两组治疗前NRS评分比较,差异无统计学意义(P>0.05);两组治疗后NRS评分比较,差异无统计学意义(P>0.05);两组治疗后NRS评分明显低于治疗前,差异有高度统计学意义(P<0.01)。结论中药穴位贴敷可有效预防和治疗奥施康定相关性便秘的发生,其效果与乳果糖口服相似。

Objective To evaluate the effect of acupoint application of traditional Chinese medicine on constipation related to Oxkangding in cancer patients.Methods Seventy-two cases of cancer patients with constipation caused by Oxycontin were selected in Oncology Department of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January 2017 to June 2019.The patients who met the criteria were divided into treatment group(36 cases,acupoint application of traditional Chinese medicine)and control group(36 cases,oral Lactulose)by random number table method.The incidence of constipation,bowel function,quality of life[Karnofsky performance status(KPS)]and pain[numeric rating scale(NRS)]score between two groups was observed.Results There was no significant difference in incidence of constipation between two groups(P>0.05).There was significant difference in incidence of constipation between treatment period and follow-up period in treatment group(P<0.05).There was significant difference in incidence of constipation between treatment period and follow-up period in control group(P<0.05).The differences were statistically significant between two groups in incidences of fecal restlessness,abdominal distention and abdominal pain before defecation(P<0.05),and there was no statistically significant difference between two groups in incidence of hard stool(P>0.05).There was no significant difference in KPS scores between two groups before treatment(P>0.05).There was no significant difference in KPS scores between two groups after treatment(P>0.05).The KPS scores in two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.01).There was no significant difference in NRS score between two groups before treatment(P>0.05).There was no significant difference in NRS score between two groups after treatment(P>0.05).The NRS scores in two groups after treatment were lower than those before treatment, the defferences were statistically significant (P < 0.01). Conclusion Acupoint application of traditional Chinese medicine can effectively prevent and treat constipation caused by Oxycontin, and its effect is similar to Lactulose.