沈阳地区体检人群骨密度调查及其影响因素分析

A survey on bone mineral density in physical examination population in Shenyang City and its influencing factors

目的调查沈阳地区体检人群的骨密度情况,并对其相关因素进行分析。方法选取本院体检的人群1138例为研究对象,采用超声骨密度仪测定体检者手部骨质,并收集血常规、肝肾功能、血脂水平、血糖、血压及年龄、病史等一般资料。结果204例患有骨质疏松症,患病率为17.9%(204/1138),随着年龄增长男女骨质疏松检出率逐渐升高,当年龄≥50岁,男性骨质疏松率为19.0%(74/389),女性骨质疏松率为35.9%(88/245),男女骨质疏松率比较差异有统计学意义(P<0.05);骨质疏松症的单因素分析发现,年龄、收缩压、红细胞计数、血红蛋白、谷氨酰基转移酶、碱性磷酸酶、总胆固醇、载脂蛋白A1、载脂蛋白B差异均有统计学意义(P<0.05);Logistic回归分析结果显示,年龄大、碱性磷酸酶水平高是骨质疏松的独立危险因素(P<0.05)。结论沈阳地区人群年龄大、碱性磷酸酶水平高是骨质疏松的重要风险因素。

Objective To investigate the bone mineral density(BMD)of physical examination population in Shenyang City and analyze its related factors.Methods A total of 1138 people who had physical examination in our hospital were selected as research objects.The hand bone was measured by ultrasonic bone densitometer,and the general data such as blood routine,liver and kidney function,blood lipid level,blood glucose,blood pressure,age,medical history were collected.Results There were 204 cases with osteoporosis,with the prevalence rate of 17.9%(204/1138).With the increase of age,the detection rate of osteoporosis increased gradually.When the patients aged≥50 years,the osteoporosis rate was 19.0%(74/389)in males,and 35.9%(88/245)in females.There was a significant difference in osteoporosis rate between male and female(P<0.05).Univariate analysis showed that age,systolic blood pressure,red blood cell count,hemoglobin,glutamyltransferase,alkaline phosphatase,total cholesterol,apolipoprotein A1,apolipoprotein B were all statistically significant(P<0.05);the results of Logistic regression analysis showed that aging and higher level of alkaline phosphatase were independent risk factors of osteoporosis(P<0.05).Conclusion Aging and higher level of alkaline phosphatase are important risk factors of osteoporosis in Shenyang City.