血常规相关指标在急、慢性自发性荨麻疹患者中的对比研究

The analysis of blood routine related indicators of acute urticaria and chronic spontaneous urticaria

目的:了解血常规相关指标在急、慢性自发性荨麻疹患者中的水平并探讨其临床意义。方法:回顾性分析本院就诊的178例急性自发性荨麻疹患者、118例慢性自发性荨麻疹患者和119例健康对照者的血常规结果,比较三组间的差异。结果:急性自发性荨麻疹组白细胞计数、中性粒细胞总数、单核细胞数、中性粒细胞与淋巴细胞比值(NLR)均高于其他两组,血小板、血小板与淋巴细胞的比值(PLR)均低于其他两组,差异均具有统计学意义(P值均<0.05);淋巴细胞总数、系统性免疫性炎症指数(SII)均高于健康对照组,嗜碱性粒细胞总数低于健康对照组,但与慢性组间比较均无统计学差异(P值均>0.05);三组间嗜酸性粒细胞总数、平均血小板压积(MPV)亦无统计学差异(P值均>0.05)。慢性自发性荨麻疹组白细胞计数、中性粒细胞总数、淋巴细胞总数、单核细胞数高于健康对照组,PLR低于健康对照组,差异均有统计学意义(P值均<0.05);而嗜酸性粒细胞、血小板、嗜碱性粒细胞、平均血小板压积、NLR、SII与健康对照组比较差异均无统计学意义(P值均>0.05)。WBC、NEU、MONO的ROC曲线下面积分别为0.734、0.701、0.709,均大于0.7;其余指标ROC曲线下面积均小于0.7。结论:急、慢性自发性荨麻疹的血常规相关指标存在一定差异,白细胞、中性粒细胞和单核细胞计数可能对急、慢性自发性荨麻疹的鉴别诊断具有一定价值,对预测急性自发性荨麻疹的转归有一定的帮助。

Objective:To investigate the expression of blood routine related indicators in acute and chronic spontaneous urticaria and its clinical significance.Methods:The blood routine test was measured in 178 patients with acute urticaria,118 patients with chronic urticaria and 119 healthy people.The differences among the third groups were compared.Results:The WBC,NEUT,MONO and NLR were significantly higher in acute urticaria group than those in the chronic urticaria group and the control group(P<0.05).The PLT and PLR in the acute urticaria group was significantly lower than the chronic urticaria group and the control group(P<0.05).The LY and SII were significantly higher in acute urticaria group than those in the control group(P<0.05),and the BASO were significantly lower in acute urticaria group than those in the control group(P<0.05),but there was no significant difference between the acute urticaria group and the chronic urticaria group(P>0.05).The WBC,NEUT,LY,and MONO were significantly higher in chronic urticaria group than those in the control group(P<0.05).The PLR in the chronic urticaria group was significantly lower than the control group(P<0.05).There was no significant difference between the chronic urticaria group and the control group for the EOS,PLT,BASO,MPV,NLR,SII(P>0.05).The AUC of ROC curve of WBC,NEU,MONO were 0.734,0.701,0.709,respectively.Conclusion:The WBC,NEU and MONO of the patients with urticaria could be used for provide more reference for clinical diagnosis and treatment of urticaria.