非编码RNA与血脂代谢的研究进展

Research progress on non-coding RNA and blood lipid metabolism

冠心病的主要病理学基础是动脉粥样硬化,其发生发展是多因素、多步骤的,也是遗传和环境因素交互作用的结果。除年龄、性别、肥胖、吸烟、高血压、糖尿病等因素外,血脂代谢异常是促进动脉粥样硬化发生发展的重要因素。越来越多的证据表明非编码RNA参与调控过程,在血脂代谢和动脉粥样硬化的形成过程中发挥重要作用,特别是使用小干扰RNA(small interfering RNA,siRNA)从RNA水平调控血脂的RNA干扰(RNA interfering,RNAi)技术,不仅在动物实验上获得了明显的降脂效果,而且在临床试验上也取得了明显疗效。本文从非编码RNA的水平总结血脂代谢的影响因素及相关干预手段。

Atherosclerosis is the main pathological basis of coronary heart disease. It is a complicated progress involved many factors,and the result of the interaction between genetic and environmental factors.In addition to factors such as age,gender,obesity,smoking,hypertension and diabetes,abnormal lipid metabolism is a particularly important factor in promoting the development of atherosclerosis.Nowadays,there is increasing evidence that non-coding RNA is involved in the regulation process and plays an important role in the lipid metabolism and formation of atherosclerosis. Especially,the RNA interference(RNAi)using small interfering RNA(siRNA)has achieved significant lipid-lowering effects not only in animal experiments,but also in clinical trials.This article reviewed influencing factors of lipid metabolism and related interventions on non-coding RNA level.