定咳汤治疗感染后咳嗽的临床研究

Clinical study of Dingke Decoction in treating cough after infection

目的观察定咳汤对感染后咳嗽的治疗效果。方法选取2017年11月至2019年6月上海市静安区中心医院中医科以及呼吸内科收治的符合感染后咳嗽诊断标准的患者478例,按照随机数表法分为中医治疗组和对照组,每组239例。对照组患者给予镇咳治疗,中医治疗组患者给予定咳汤治疗,疗程均为1周,治疗结束后,比较两组患者的临床治疗效果、治疗前后咳嗽症状评分以及生活质量评分。结果中医治疗组患者的治疗总有效率为89.96%,明显高于对照组的71.13%,差异具有统计学意义(P<0.05);治疗前,中医治疗组患者的日间、夜间咳嗽症状评分及视觉模拟评分分别为(2.16±0.45)分、(2.37±0.49)分和(6.64±0.80)分,分别与对照组的(2.21±0.47)分、(2.40±0.52)分和(6.63±0.77)分比较差异均无统计学意义(P>0.05);治疗后,中医治疗组患者的日间、夜间咳嗽症状评分及视觉模拟评分分别为(0.36±0.14)分、(0.38±0.17)分和(0.95±0.37)分,明显低于对照组的(0.58±0.24)分、(0.62±0.20)分和(1.56±0.43)分,差异均具有统计学意义(P<0.05);治疗前,中医治疗组患者的社会、心理、生理及总分与对照组比较差异均无统计学意义(P>0.05);治疗后,中医治疗组患者的社会、心理、生理及总分分别为(24.62±5.19)分、(40.37±7.51)分、(50.50±6.13)分和(115.49±18.83)分,明显高于对照组的(18.28±4.03)分、(34.50±6.61)分、(45.27±5.94)分和(98.05±16.58)分,差异均具有统计学意义(P<0.05)。结论与传统的病因治疗相比,定咳汤对感染后咳嗽的患者临床治疗效果确切,可显著减轻患者的咳嗽症状,提高患者的生活质量。

Objective To study the therapeutic effect of Dingke Decoction on cough after infection. Methods A total of 478 patients who met the diagnostic criteria for post-infection cough admitted to the Department of Traditional Chinese Medicine and Respiratory Department of Shanghai Jing’ an District Central Hospital from November 2017 to June 2019 were randomly divided into TCM treatment group and control group according to the random number table method, with 239 patients in each group. Patients in the control group were treated with etiological therapy and antitussive therapy, while patients in the TCM treatment group were treated with Dingke Decoction for 1 week. After treatment,the clinical therapeutic effects, cough symptom scores, and quality of life scores of the two groups were compared.Results The total effective rate of TCM treatment group was 89.96%, significantly higher than 71.13% of the control group(P<0.05). Before treatment, the daytime and nighttime cough symptom scores and visual analogue scores of the patients in the TCM treatment group were(2.16±0.45) points,(2.37±0.49) points, and(6.64±0.80) points, respectively,which showed no significant difference as compared with(2.21±0.47) points,(2.40±0.52) points, and(6.63±0.77) points of the control group(P>0.05). After treatment, the daytime and nighttime cough symptom scores and visual analogue scores of patients in the TCM treatment group were(0.36±0.14) points,(0.38±0.17) points, and(0.95±0.37) points, respectively, significantly lower than(0.58±0.24) points,(0.62±0.20) points, and(1.56±0.43) points in the control group(P<0.05). Before treatment, there was no significant difference in social, psychological, physiological and total scores between the TCM treatment group and the control group(P>0.05). After treatment, the social, psychological, physiological and total scores of the patients in the TCM treatment group were(24.62±5.19) points,(40.37±7.51) points,(50.50±6.13) points, and(115.49±18.83) points, respectively, which were significantly higher than(18.28±4.03) points,(34.50±6.61) points,(45.27±5.94) points, and(98.05±16.58) points in the control group(P<0.05). Conclusion Compared with traditional etiological treatment, Dingke Decoction has definite clinical therapeutic effect on patients with post-infection cough, which can significantly reduce cough symptoms and improve the quality of life of patients.