持续均匀性肠内营养支持对胃食管反流患者免疫功能及短期转归的影响

The effect of continuous homogeneity enteral nutrition support on immune function and short-term outcome in patients with gastroesophageal reflux

目的研究持续性肠内营养支持对胃食管反流病患者免疫功能和短期转归的影响。方法纳入90例胃食管反流病患者作为研究对象,随机抽签分为两组,每组各45例。两组均行奥美拉唑治疗,观察组行持续性泵入肠内营养液干预,对照组行常规鼻饲干预。比较两组患者免疫功能、营养状态及治疗后短期转归。结果观察组治疗后CD3<+和CD4<+显著高于对照组,CD8<+显著低于对照组,差异均有统计学意义(P<0.05)。两组治疗前后CD4<+/CD8<+比较,差异均无统计学意义(P>0.05)。两组治疗后反流次数、反流时间、pH<4时间、LESP及LESL水平均显著低于治疗前,差异有统计学意义(P<0.05),观察组治疗后反流次数和反流时间显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后营养状态显著优于对照组,差异有统计学意义(P<0.05)。观察组食管反流发生率显著低于对照组,差异有统计学意义(P<0.05)。结论持续均匀性肠内营养支持有助于改善胃食管反流病患者免疫功能,较传统定期鼻饲干预治疗效果更好。

Objective To study the effect of continuous homogeneity enteral nutrition support on immune function and short-term outcome in patients with gastroesophageal reflux.Methods 90 cases of gastroesophageal reflux disease were included in the study and were divided into two groups by random draw,45 cases in each group.The two groups were treated with omepr3333azole,the observation group were received the intervention of continuous pumping enteral nutrient solution,the control group were received the routine nasal feeding intervention.The immune function,nutritional status and short-term outcome after treatment were compared between the two groups.Results The CD3<+and CD4<+in the observation group were significantly higher than those in the control group,the CD8<+was significantly lower than that of the control group,the difference were statistically significant(P<0.05).There were no significant difference in the difference between the two groups of the CD4<+/CD8<+before and after treatment(P>0.05).The reflux times,reflux numbers,pH<4 time,LESP and LESL levels of the two groups after treatment were significantly lower than those before treatment(P<0.05).The reflux times and reflux numbers after treatment in the observation group were significantly lower than those of the control group(P<0.05).The nutritional status of the observation group was significantly better than that of the control group,the difference was statistically significant(P<0.05).The rate of esophageal reflux in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The continuous homogeneity of enteral nutrition support can improve the immune function of patients with gastroesophageal reflux disease,and the effect is better than that of traditional regular nasal feeding.