卵巢癌中相关长链非编码RNA的研究进展

Reseach Progress of Epithelial Ovarian Cancer Related Long Non-Coding RNA

卵巢癌是女性生殖系统第二常见的恶性肿瘤,其发生发展涉及多种遗传学和环境因素,其生存率低及易复发性已成为研究的重点和难点。基因组计划近年的研究显示,在基因组序列中仅有不到2%的核酸序列可用于编码蛋白质,其余98%以上的序列不编码任何蛋白质,这些基因序列一度被认为是"无功能序列",但是近年来的研究却表明这些无功能序列蕴含着丰富的信息和功能。这些"无功能序列"中大多数为长度超过200个碱基的长链非编码RNA(lncRNA)。LncRNA是由哺乳动物基因组编码的长度超过200 bp的一组内源性细胞RNA,近年来学者们己经发现了许多与恶性肿瘤有关的lncRNA,并认为它们可能在调控肿瘤发生、发展及侵袭过程中发挥作用。本文概述了lncRNA在卵巢癌中的研究进展。

Ovarian cancer is the second most common malignant tumor in the female reproductive system. Its development involves a variety of genetic and environmental factors. Its low survival rate and easy recurrence have become the focus and difficulty of research. The genome project has shown in recent years that less than 2% of the nucleic acid sequences in the genome sequence can be used to encode proteins, and the remaining 98% of the sequences do not encode any proteins. These gene sequences were once considered "non-functional sequences", but recent studies have shown that these non-functional sequences contain a wealth of information and functions. Most of these non-functional sequences are long non-coding RNAs(lncRNAs) with more than 200 bases.Lnc RNAs are a group of endogenous cellular RNAs encoded by the mammalian genome that are more than 200 bp in length. Many researchers at home and abroad have discovered a few lnc RNAs related to malignant tumors, and they believe that lnc RNAs may play a role in regulating tumorigenesis and invasion. This article summarizes the research progress of lnc RNA in ovarian cancer.