围绝经期女性代谢综合征的相关研究进展

Advances in Research on Metabolic Syndrome in Perimenopausal Women

代谢综合征(MS)严重威胁围绝经期女性的健康和生活质量。糖尿病、血脂异常是其重要的组成部分,其中心环节是腹型肥胖和胰岛素抵抗。围绝经期女性由于卵巢功能的衰退,性激素水平发生一系列改变,对血脂代谢和骨密度均有一定的影响。但该阶段女性发展为MS的具体机制尚未完全阐明。遗传因素和环境因素可影响围绝经期女性MS的发生,个体化生活方式干预和激素替代治疗可以降低绝经妇女MS的发生率。现对女性性激素与MS的关系、MS的流行概况、治疗和管理等进行综述。

Metabolic syndrome is a serious threat to the health and quality of life of perimenopausal women. Diabetes and dyslipidemia are main parts of it,its central link is abdominal obesity and insulin resistance. Due to the decline of ovarian function,sex hormone levels of perimenopausal women have a series of changes, which have a certain impact on lipid metabolism and bone mineral density. However, the specific mechanism of women developing MS at this stage has not been fully clarified. Genetic factors and environmental factors may be related to the occurrence of MS in perimenopausal women. Individualized life style interventions and hormone replacement therapy can reduce the incidence of MS in postmenopausal women. This article reviews the relationship between female sex hormones and MS, the prevalence, treatment as well as management of MS.