SIRT1通过抑制卵母细胞衰老改善卵巢储备功能的研究进展

Research Progress on SIRT1 Improving Ovarian Reservation by Inhibiting Oocyte Senescence

卵母细胞衰老及卵巢储备功能降低所造成的生育力下降是生殖领域的瓶颈问题,改善卵巢储备功能是提高不孕女性自然妊娠率及辅助生殖技术(ART)成功率的重要因素。沉默信息调节因子2相关酶类1(SIRT1)是调节卵子发生和细胞应激反应关键过程的重要参与者,可通过调控卵母细胞数量、改善卵母细胞质量、抑制氧化应激、调节线粒体功能等途径抑制卵母细胞衰老,提高卵巢储备功能,延长卵巢寿命,进而增加ART过程中的获卵数、成胚率及临床妊娠率。综述SIRT1通过抑制卵母细胞衰老改善卵巢储备功能的相关机制研究进展。

The fertility decline caused by oocyte aging and the decreased ovarian reservation is a bottleneck problem in the field of reproduction,Improving ovarian reserve function is an important factor to improve the natural pregnancy rate and ART success rate of infertile women. It has been found that sirtuin 1(SIRT1) is an important player in regulating the key processes of oogenesis and cellular stress response. SIRT1 can inhibit oocyte senescence by regulating oocyte number, improving oocyte quality, inhibiting oxidative stress and regulating mitochondrial function. Therefore, SIRT1 can improve the ovarian reserve function and prolong ovarian life. SIRT1 can also increase the number of eggs, embryo formation rate and clinical pregnancy rate during assisted reproductive technology(ART). This paper reviews the research progress on SIRT1 in improving ovarian reserve function by inhibiting oocyte senescence.