新辅助化疗在局部晚期宫颈癌中的疗效研究

Advances in the Efficacy of Neoadjuvant Chemotherapy in Local Advanced Cervical Cancer

宫颈癌是全球女性生殖系统最常见的恶性肿瘤,发病率位居女性恶性肿瘤的第3位,超过50%以上的患者就诊时已为局部晚期。局部晚期宫颈癌(local advanced cervical cancer,LACC)具有易侵袭、淋巴转移率高、手术困难、易复发等特点,疗效不确定,目前仍没有统一的治疗方案。研究发现新辅助化疗(neoadjuvant chemotherapy,NACT)能够缩小肿瘤大小,提高手术切除率及手术效果,增加放疗敏感性,降低复发率和转移率,可改善LACC的预后。同时研究发现对于需保留生育功能及合并妊娠的特殊患者来说,NACT可以控制病情,延长孕周,改善母儿结局。综述NACT在LACC的的疗效。

Cervical cancer is the most common malignant tumor in the female reproductive system in the world, ranking the third in the incidence of female malignant tumor. Local advanced cervical cancer(LACC) is characterized by being easy to invade, high rate of lymphatic metastasis, difficulty of operation, and being easy to relapse. The curative effect is uncertain, and there is still no unified treatment program. The study found that neoadjuvant chemotherapy(NACT) could reduce tumor size, improve surgical resection rate and surgical effect,increase radiotherapy sensitivity, reduce recurrence rate and metastasis rate, and improve the prognosis of LACC.At the same time, it was found that NACT could control the disease, prolong the gestation period and improve the outcomes of mother and child for special patients who need to retain the reproductive function and the complicated pregnancy. Therefore, this article reviews the efficacy of NACT in LACC.