载药聚偏氟乙烯伤口敷料的制备及其性能

Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings

为获得轻薄柔软的伤口敷料,并使其具备优异的压电和抗菌性能,以聚偏氟乙烯(PVDF)为原料,掺杂不同质量分数的盐酸恩诺沙星(Enro),采用静电纺丝技术制备载药PVDF复合纳米纤维膜。分析了复合纳米纤维膜的形貌、化学结构对其压电性能、药物缓释和抗菌性能的影响。结果表明:PVDF质量分数为8%时,纤维平均直径为(753±128)nm,纤维网成膜良好,复合纳米纤维膜直径随着Enro质量分数的增加呈先增大后减小趋势;纺丝过程中PVDF由α晶型转变为β晶型,使纤维膜具备了压电性能,可产生9 mV的输出电压;当Enro质量分数为15%时,纤维膜释药速度平稳、持续时间长且具备优异的抗菌性能,适合用作伤口敷料。

With the aim of obtaining thin and soft wound dressings with excellent piezoelectric and antibacterial functions,drug-loaded(PVDF)composite nanofiber membranes were prepared by electrospinning from PVDF and enrofloxacin hydrochloride(Enro)at different mass ratios.The influence of morphology and chemical structure of the composite nanofiber membrane on its piezoelectricity,sustained release and antibacterial properties were investigated.Results show that in the situation where the mass ratio of PVDF was 8%and the average fiber diameter was(753±128)nm,the fiber membrane showed good web formation.It is revealed that the diameter of composite nanofiber increased and then decreased as the Enro mass fraction was incremented,and that the crystal structure of PVDF changed fromαtoβcrystal phase after the process of electrospinning,leading to an excellent piezoelectric properties with a 9 mV output voltage.When the mass concentration of Enro was 15%,the drug-loaded PVDF composite nanofiber membrane exhibited a relatively stable and sustainable release and outstanding antibacterial performance.The drug-loaded PVDF composite nanofiber membrane is proven to be suitable for wound dressings.