基于有氧糖酵解的破血药化瘀散结抗肿瘤及肿瘤转移的分子基础探讨

Forecasting the Mechanism on Anti-Tumor and Anti-Metastasis of Blood-Breaking Drugs Based on Aerobic Glycolysis

化瘀散结法是中医临床抗肿瘤的重要治法之一,从肿瘤血瘀证辨证出发,使用活血化瘀药尤其以破血药为主的中药复方,通过化瘀散结作用治疗肿瘤取得了不错的效果。关于破血药是否具有抗肿瘤作用尚存在争议,目前有临床研究发现破血药可能会促进肿瘤转移,但多数的基础研究均显示破血药可以抗肿瘤转移。通过结合现代医学理论,明确破血药的抗肿瘤及肿瘤转移作用,并进一步提出该作用的潜在分子基础,即破血药可能通过干扰肿瘤的有氧糖酵解过程,抑制肿瘤生长及转移。从糖酵解这一能量代谢过程中研究破血药的抗肿瘤及肿瘤转移机制,揭示化瘀散结法治疗肿瘤的现代分子基础之一,为破血药的抗肿瘤及肿瘤转移研究提供了一个新的思路,也为临床破血药抗肿瘤应用提供依据。

Huayu Sanjie is one of the important principles of anti-tumor in clinical Chinese medicine.From the dialectical of blood stasis syndrome,the use of activating blood and removing phlegm drugs,especially the traditional Chinese medicine compound based on blood-breaking drugs,which is used to treat tumors through Huayu Sanjie makes a good result.There is controversy about whether blood-breaking drugs have anti-tumor effects.At present,clinical studies have found that blood-breaking drugs may promote tumor metastasis,but most basic studies have shown that blood-breaking drugs can resist tumor metastasis.The purpose of this paper is to determine the anti-tumor and tumor metastasis effects of blood-breaking drugs by combining modern medical theories,and further propose the potential molecule mechanism of this effect,that is,blood-breaking drugs may interfere with the aerobic glycolysis process of tumors,and inhibit tumor growth and metastasis.In this paper,the anti-tumor and tumor metastasis molecule mechanism of blood-breaking drugs was studied for the first time from the energy metabolism process of glycolysis,which provided a new idea for the anti-tumor and anti-metastatic research of blood-breaking drugs,and provides a basis for the anti-tumor application of clinical blood-breaking drugs.