红花黄色素对胸腔镜食管癌根治术后早期并发症发生率的影响

Effects of Safflower Yellow on the Incidence of Early Complications after Thoracoscopic Esophagectomy for Esophageal Cancer

目的:探讨红花黄色素对胸腔镜食管癌根治术后早期并发症发生率的影响。方法:选取2015年6月至2016年4月泉州海峡医院收治的行胸腔镜食管癌根治术的患者30例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组15例。对照组术后给予常规治疗,观察组在术后2~3 d无明显活动性出血时联合红花黄色素连续治疗2周。统计2组患者临床治疗有效率;检测2组患者术前及术后2周后肺功能情况;统计2组患者术后早期并发症的发生率;检测并记录2组患者术前及术后不同时间创伤应激反应指标变化情况。结果:术后2周观察组临床治疗有效率明显高于对照组,差异有统计学意义(P<0.05);与术前比较,术后2周2组患者第一秒钟用力呼气量(FEV 1)、第一秒钟用力呼气量占预计值百分比(FEV 1%)、用力肺活量(FVC)、用力肺活量占预计值百分比(FVC%)水平均降低,但观察组差异无统计学意义(P>0.05),对照组差异有统计学意义(P<0.05),且观察组显著高于对照组,差异有统计学意义(P<0.05);观察组患者吻合口瘘、切口感染、肺部并发症和心脏并发症的发生率显著低于对照组,差异有统计学意义(P<0.05);观察组每日胸腔引流液量显著多于对照组,拔管时间显著长于对照组,差异有统计学意义(P<0.05);术后1周,观察组白细胞、C反应蛋白(CRP)、游离甲状腺素(FT 4)水平显著低于对照组,差异有统计学意义(P<0.05)。结论:红花黄色素可有效降低行胸腔镜食管癌根治术患者术后早期并发症的发生率,减弱机体创伤的氧化应激反应,改善肺功能,提高临床治疗有效率,且疗效优于常规治疗。

Objective:To investigate the effects of safflower yellow on the incidence of early complications after thoracoscopic esophagectomy for esophageal cancer.Methods:A total of 30 patients who underwent thoracoscopic esophagectomy in Quanzhou Strait Hospital from June 2015 to April 2016 were selected and divided into a control group(n=15)and an observation group(n=15)according to random number table method.The control group was given routine treatment,while the observation group was treated with safflower yellow for 2 weeks without obvious active hemorrhage 2-3 days after operation.The total clinical effective rate of the 2 groups was counted;the pulmonary function of the 2 groups was tested before and after 2 weeks of operation;the incidence of early complications after operation was counted;the changes of trauma stress response indexes before operation and 1 day after operation and 1 week after operation were measured and recorded in the 2 groups.Results:After 2 weeks of operation,the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05);compared with pre-operation,the levels of FEV 1,FEV 1,FVC and FVC%in the 2 groups decreased after 2 weeks of operation,but there was no significant difference between the observation group and the control group(P>0.05),and the observation group was markedly higher than the control group(P<0.05).;the incidence of anastomotic leakage,incision infection,pulmonary complications,cardiac and complications in the observation group was significantly lower than that in the control group(P<0.05);the daily volume of thoracic drainage fluid in the observation group was significantly more than that in the control group,and the extubation time was dramatically longer than that in the control group(P<0.05);and the incidence of WBC,CRP and FT 4 in the observation group was significantly lower than that in the control group.The level was substantially lower than that of the control group(P<0.05).Conclusion:Safflower yellow can effectively reduce the incidence of early complications in patients undergoing thoracoscopic esophagectomy for esophageal cancer,reduce oxidative stimulus response to trauma,improve pulmonary function,and improve the total clinical efficiency,and the curative effect is better than conventional treatment,which is worthy of clinical application.