射干麻黄汤对治疗哮喘作用机理的研究进展

Research Progress on the Mechanism of Shegan Mahuang Decoction in the Treatment of Asthma

哮喘是一种常见的具有复杂性状的,具有多基因遗传倾向的呼吸道疾病,射干麻黄汤在治疗哮喘方面,有显著疗效,此方出自我国现存最早的一部杂病类医书《金匮要略》的第七篇。本综述综合近年来射干麻黄汤对细胞白细胞介素(包括细胞白细胞介素IL-4、IL-5、IL-6、IL-13、IL-17、IL-10)与过氧化物酶体增殖剂激活受体(PPARs)中PPARγ亚型及其配体结合两方面的影响,对气道重塑的分析,嗜酸性粒细胞的凋亡,以及在临床方面的相关研究,作出进一步总结,进而深度探寻射干麻黄汤对治疗哮喘的作用机理,对未来治疗哮喘提供相关借鉴方案。

Asthma is a common respiratory disease with complex characters and tendency of polygenic inheritance.In the ancient Chinese book Synopsis of Golden Chamber:the earliest medical book of miscellaneous diseases,there were the records of Shegan Mahuang Decoction was highly curative in the treatment of asthma.This paper reviewed an integration of the effects of Shegan Mahuang Decoction on interleukin(including interleukin IL-4,IL-5,IL-6,IL-13,IL-17,IL-10)and on peroxisome proliferator-activated receptorγexpressions and its ligand-binding,the analysis of airway remodeling,the apoptosis of eosinophils and related clinical research,and made a further summary,so as to further explore the mechanism of action of Shegan Mahuang Decoction on asthma and provide relevant reference plans for future treatment of asthma.