中国医院药物警戒系统对某院药品不良反应上报的影响

Effect of Chinese Hospital Pharmacovigilance System on the Reporting of Adverse Drug Reactions in a Hospital

目的探讨中国医院药物警戒系统(CHPS)对医院药品不良反应(ADR)上报的影响。方法以安装CHPS前、后医院ADR报告表情况为对照组和研究组,通过数据汇总统计分析,比较同期两组ADR上报的数量、新的/严重的比例、报表缺项以及ADR过程描述等方面的情况。结果研究组ADR上报数量明显提升,增加幅度达181.25%。描述完整性平均得分由2.28分上升到2.87分;新的/严重的ADR报告的比例达到50.0%,报表缺项明显减少(P<0.05),对ADR过程描述更详细。结论CHPS具有方便、实用、快捷等优势,对医院ADR上报的数量及质量有明显提升作用。

Objective To explore the effect of Chinese Hospital Pharmacovigilance System(CHPS)on reporting adverse drug reaction(ADR)in hospitals.Methods The ADR report form before the installation of CHPS was used as the control group,and the ADR report in the same period after the installation of CHPS was used as the research group.The number of ADR reports,new cases/serious cases proportion,missing items reporting,and ADR process descriptions of the two groups in the same period were compared through data collection and statistical analysis.Results After the installation of CHPS,the number of ADR reports increased significantly at the percentage of 181.25%.The proportion of new/serious ADR reports reached 50%,and the number of missing items in the reports decreased significantly(P<0.05).And the ADR process description was more detailed.Conclusion The CHPS system has the advantages of convenience,practicality,and rapidity.And it has a significant effect on the quantity and quality of ADR reporting in our hospital.