急性胆源性胰腺炎肝损伤研究进展

Progress in research of liver injury induced by acute biliary pancreatitis

急性胆源性胰腺(acute biliary pancreatitis,ABP)不仅存在胰腺的急性炎症,还往往合并胆道系统的梗阻或感染,肝功能损伤是ABP最常见的并发症之一,病理机制主要包括感染和内毒素、胆汁淤积、胰酶损伤、微循环障碍和氧化应激等,其研究结论多来源于动物实验.在内科常规治疗ABP基础上,积极抗感染治疗和尽快解除胆道梗阻能促进ABP相关肝损伤的恢复.

Acute biliary pancreatitis(ABP)not only causes acute inflammation of the pancreas,but also leads to obstruction or infection of the biliary system.Liver injury is one of the most common complications of ABP.The pathological mechanisms mainly include infection and endotoxin,cholestasis,pancreatic enzyme damage,microcirculatory disorders,and oxidative stress,and the research conclusions are mostly derived from animal experiments.On the basis of routine medical treatment of ABP,active anti-infective treatment and rapid relief of biliary obstruction can promote the recovery of ABPrelated liver injury.