辣椒素对消化系统肿瘤防治的研究进展

Progress in understanding role of capsaicin in prevention and treatment of digestive system tumors

放化疗仍是目前恶性肿瘤的主要治疗方式,但是放化疗的副作用依然无法忽视,寻找天然活性物质对肿瘤进行防治则引起了广泛的关注.辣椒素(capsaicin,Cap)是辣椒辣味物质的主要活性成分,自20世纪以来,人们对于Cap的临床作用的研究越来越多,Cap的抗肿瘤作用也正是目前研究的热点,其抗肿瘤作用机制复杂,可引起肿瘤细胞增殖抑制、凋亡、自噬,抑制肿瘤细胞迁移及侵袭,抗血管生成,以及增加其他化疗药物疗效等作用,是抗肿瘤的潜在药物,具有广阔前景.本文就Cap对消化系统肿瘤的防治作用及机制进行综述.

Radiation and chemotherapy are still the main treatments for malignant tumors,but their side effects are significant.Thus,searching natural active substances for the prevention and treatment of tumor has attracted wide attention.Capsaicin(Cap)is the main active ingredient in chili hot material.Since the 20th century,more and more studies have been performed on the clinical effects of Cap,and its antitumor function has become a currently hot research topic.The antitumor mechanism of Cap is complex,and it can cause tumor cell proliferation inhibition,apoptosis,and autophagy,inhibit tumor cell migration and invasion,and have an anti-angiogenesis property.As a potential anti-tumor drug,Cap has a broad prospect to increase the efficacy of other chemotherapy drugs.This paper reviews the role of Cap in the prevention and treatment of digestive system tumors and discusses the possible mechanisms involved.