老年急性髓系白血病患者预后的影响因素分析

Analysis of Factors Influencing Prognosis of Elderly Patients with Acute Myeloid Leukemia

目的分析老年急性髓系白血病患者预后的影响因素。方法对苏州大学附属张家港医院(张家港市第一人民医院)2013年1月至2017年12月收治的92例老年急性髓系白血病患者的临床资料进行回顾调查,分析影响患者预后的危险因素。结果本研究92例患者中,完全缓解26例(28.3%),中位生存期221 d;未缓解66例(71.7%),中位生存期102 d。影响因素分析显示,年龄≤70岁、功能状态评分(PS评分)<2分、初治时的白细胞计数≤50×10^9/L、接受标准化疗、白细胞CD34表达阴性、染色体低危核型的患者完全缓解率升高、中位生存期延长(P<0.05)。结论影响老年急性髓系白血病患者预后的危险因素为年龄、功能状态评分、初治时的白细胞计数、治疗方案及染色体核型。

Objective To analyze the influencing factors of prognosis in elderly patients with acute myeloid leukemia.Methods The clinical data of 92 elderly patients with acute myeloid leukemia admitted to Zhangjiagang Hospital Affiliated to Suzhou University(First People's Hospital of Zhangjiagang City)from January 2013 to December 2017 were retrospectively analyzed to analyze the risk factors affecting the prognosis of patients.Results Of the 92 patients in the study,26(28.3%)had complete remission,with a median survival of 221 days;66 patients(71.7%)had no remission,with a median survival of 102 days.Analysis of influencing factors showed that patients with age≤70 years,PS score<2 points,white blood cell count≤50×10^9/L at initial treatment,standard chemotherapy,white blood cell CD34 expression negative,chromosome low-risk karyotype patients had increased complete remission rate and prolonged median survival time(P<0.05).Conclusion The risk factors for prognosis in elderly patients with acute myeloid leukemia are age,functional status score,white blood cell count at initial treatment,treatment regimen,and karyotype.