基于复杂网络的磁刺激内关穴脑皮层功能连接分析

Cerebral Cortex Functional Connection Analysis of Magnetic Stimulation at Neiguan Acupoint (PC6) Based on Complex Network

将磁刺激技术、脑电图与传统穴位理论相结合,研究穴位刺激引发的大脑皮层功能网络协同调控过程。利用组独立成分分析、标准低分辨率脑电磁断层成像,对14名健康被试静息态、磁刺激内关穴的脑电信号进行反演,确定脑网络节点。通过短时傅里叶变换和互相关方法,计算α频段功率谱间的互相关系数,基于t检验、错误发现率,校正(FDR)构建脑网络连接边(P<0.05,FDR校正),并对脑皮层功能连接进行分析。结果表明,磁刺激时与运动相关脑区节点的功能连接减少22.9%,与情绪、记忆相关脑区节点的功能连接增多93.8%,位于额叶和颞叶节点的功能连接增多21.2%。磁刺激内关穴引起的脑皮层功能网络拓扑结构变化与穴位自身功能相吻合,为揭示穴位调控机理提供新线索。

Combined with magnetic stimulation technique, electroencephalogram(EEG) and traditional acupoint theory, the coordinated regulation process of cerebral cortex functional network evoked by acupoint stimulation was studied in this work. The EEG signals in resting state and magnetic stimulation at Neiguan(PC6) acupoint of 14 healthy subjects were reconstructed to determine the brain network nodes, using the group independent component analysis and standard low-resolution brain electromagnetic tomography. The correlation coefficient between the alpha-band power spectrums was calculated by the short-time Fourier transform and the cross-correlation method. Based on t-test and false discovery rate correction(FDR) the brain network connection edges(P<0.05, FDR corrected) were constructed. The functional connections of cerebral cortex were analyzed. Results showed that the functional connections of nodes in brain areas related to movement decreased by 22.9%, the functional connections of nodes in brain areas associated with emotion and memory increased by 93.8%, the functional connections of nodes in the frontal lobe and temporal lobe increased by 21.2% during magnetic stimulation. The topological structure changes of the cerebral cortex functional network caused by magnetic stimulation at PC6 are consistent with the function of the acupoint. This study provides new clues for revealing the mechanism of acupoint regulation.