重症急性胰腺炎血液净化的选择

Selection of blood purification for severe acute pancreatitis

重症急性胰腺炎(severe acute pancreatitis, SAP)是一种重症炎症反应性疾病,伴有持续性器官衰竭超过48h以上,病死率高。胰酶、细胞因子的异常释放伴随着SAP的发生与进展。血液净化能够连续或间断清除体内过多水和溶质,调节促炎和抗炎因子的平衡,减轻器官功能损害,可能是一种新的有效治疗方法。但目前对应用血液净化治疗SAP仍有较多争议,该治疗尚处于探索阶段。

Severe acute pancreatitis(SAP)is a severe inflammatory disease with persistent organ failure for more than 48 hours,resulting in a high mortality rate. The abnormal release of pancreatic enzyme and cytokines is accompanied by the occurrence and progress of SAP. Blood purification can not only continuously or intermittently remove excessive water and solutes from the body,but also regulate the balance of pro-inflammatory and anti-inflammatory factors,thus reducing organ function damage,which may be a new effective treatment method for SAP. At present,the application of blood purification for SAP is still controversial and still in the exploratory stage.