重度颅脑损伤：应该预防癫痫吗？

Should prophylactic antiepileptic drugs be applied in severe traumatic brain injury?

重度颅脑损伤患者有较高概率发生癫痫,是否需要抗癫痫药物预防癫痫发作存在争议。文章认为,重度颅脑损伤患者早期(7d内)在应用镇痛镇静治疗基础上无需加用抗癫痫药物,晚期无预防性应用抗癫痫药物的必要。而确诊为癫痫者则需应用抗癫痫药物规范治疗。

The patients with severe traumatic brain injury(sTBI)have a higher incidence of epilepsy.It’s controversial whether prophylactic antiepileptic drugs(AEDs)are needed to prevent epilepsy in sTBI.Patients with sTBI do not need prophylactic AEDs on the basis of analgesic and sedative treatment in the early stage(within 7 days),and prophylactic AEDs are also not needed in late stage.Patients diagnosed with epilepsy need to take AEDs.