代谢综合征患者血脂变化对CA19-9水平影响的研究

Study on the effect of changes in serum lipid level on CA19-9 concentration in patients with metabolic syndrome

目的探讨代谢综合征(MS)患者血脂变化对CA19-9水平的影响。方法选取2018年1月至2019年9月重庆大学附属中心医院住院的482例MS患者的一般资料,测量其收缩压、舒张压、腹围,检测空腹糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、CA19-9等指标水平,比较不同CA19-9水平患者上述代谢指标的差异,分析CA19-9与各代谢指标的相关性。结果MS患者的TG、TC、LDL-C随CA19-9水平的升高而升高,呈正相关(P<0.05);HDL-C随CA19-9水平的升高而下降,呈负相关(P<0.05);TG(β′=0.214)、TC(β′=0.458)、LDL-C(β′=0.111)与CA19-9水平具有独立相关性(P<0.05)。结论MS患者TG、TC、LDL-C水平变化可能影响CA19-9水平。

Objective To investigate the effect of changes in serum lipid level on CA19-9 concentration in patients with metabolic syndrome(MS).Methods A total of 482 inpatients with MS in Central Hospital of Chongqing University from January 2018 to September 2019 were collected.Systolic blood pressure,diastolic blood pressure,abdominal circumference were measured,and glycated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),CA19-9 in fasting blood were detected.The differences of the above metabolic indexes at different CA19-9 concentrations were compared and the relationship between CA19-9 and metabolic indexes was analyzed.Results TG,TC and LDL-C in patients with MS increased with the increase of CA19-9 concentration,showing a significant positive correlation(P<0.05),while HDL-C decreased with the increase of CA19-9 concentration,showing a significant negative correlation(P<0.05).TG(β′=0.214),TC(β′=0.458),LDL-C(β′=0.111)were independently correlated with CA19-9 concentrations(P<0.05).Conclusion Changes in TG,TC and LDL-C levels in patients with MS may affect CA19-9 concentrations.