PAC-1和CD62p活化程度与ACS患者冠状动脉狭窄程度的相关性研究

Study on the correlation between activation degree of PAC-1,CD62p and severity of coronary artery stenosis in patients with ACS

目的探讨血小板膜糖蛋白纤维蛋白原受体(PAC-1)和P选择素(CD62p)的活化与急性冠状动脉综合征(ACS)患者冠状动脉狭窄严重程度的相关性。方法收集77例ACS患者(观察组)及23例非ACS患者(对照组)基本信息,采用流式细胞检测方法检测研究对象PAC-1、CD62p;通过冠状动脉造影技术对患者冠状动脉血管狭窄情况进行评估,运用Gensini评分法评分,根据分值高低将不同冠状动脉狭窄程度患者分为轻、中、重度病变组,对ACS患者的PAC-1、CD62p水平与Gensini评分进行分析对比。结果两组PAC-1及CD62p水平比较,差异有统计学意义(P<0.05)。与对照组比较,轻、中、重度病变组PAC-1、CD62p水平较高,且呈递增趋势(P<0.05)。PAC-1和CD62p水平与Gensini评分呈正相关(P<0.05)。结论PAC-1、CD62p与ACS患者冠状动脉狭窄严重程度呈正相关。

Objective To investigate the correlation between activation degree of platelet membrane glycoprotein fibrinogen receptor(PAC-1)and P-selectin(CD62p)and severity of coronary artery stenosis in patients with acute coronary syndrome(ACS).Methods Basic information of 77 ACS patients(the observation group)and 23 non-ACS patients(the control group)were collected,PAC-1 and CD62p were detected by flow cytometry,the patients with coronary artery stenosis were assessed by coronary angiography.Gensini scoring method was used for scoring,and the observation group was divided into the light,medium and heavy coronary stenosis groups according to the score.PAC-1,CD62p levels and Gensini scores of ACS patients were analyzed and compared.Results There were significant differences in PAC-1 and CD62p levels between the two groups(P<0.05).Compared with the control group,the levels of PAC-1 and CD62p in the light,medium and heavy coronary stenosis groups were higher,and it showed an increasing trend(P<0.05).PAC-1 and CD62p were positively correlated with Gensini score(P<0.05).Conclusion PAC-1 and CD62p were positively correlated with the severity of coronary artery stenosis in ACS patients.