心力衰竭患者血清TRPC1水平及其与心功能和预后的关系研究

Study on the TRPC1 level in patients with heart failure and its relationship with cardiac function and prognosis

目的探讨心力衰竭(HF)患者血清瞬时受体电位通道1(TRPC1)水平及其与心功能和预后的关系,阐明TRPC1在心力衰竭中的价值。方法选取该院心血管内科2016年1月至2018年12月80例心力衰竭患者作为HF组,选取同期80例健康体检者作为对照组。测定并比较两组血清TRPC1、脑钠肽N端前体蛋白(NT-proBNP)水平、左室射血分数(LVEF)和左室舒张末期内径(LVEDD)。结果HF组TRPC1、NT-pro BNP水平和LVEDD高于对照组,LVEF低于对照组,差异有统计学意义(P<0.05)。不同心功能HF患者TRPC1、NT-pro BNP水平和LVEF、LVEDD比较,差异有统计学意义(P<0.05),且随着心功能级别的升高,TRPC1、NT-pro BNP水平和LVEDD升高,LVEF降低。HF患者TRPC1水平与NT-pro BNP、LVEDD呈正相关(P<0.05),与LVEF呈负相关(P<0.05),TRPC1、NT-pro BNP、LVEF、LVEDD均为HF死亡的危险因素(P<0.05)。结论TRPC1在HF患者中水平升高,其为HF死亡的危险因素。

Objective To investigate the serum transient receptor potential channel 1(TRPC1)level and the relationship with cardiac function and prognosis in patients with heart failure(HF),and elucidate the value of TRPC1 in HF.Methods A total of 80 patients with HF were selected as the HF group,while 80 healthy subjects were selected as the control group from January 2016 to December 2018.TRPC1,B-type brain natriuretic peptide(NT-pro BNP)level,left ventricular ejection fraction(LVEF)and left ventricular end diastolic diameter(LVEDD)were measured and compared between the two groups.Results TRPC1,NT-pro BNP levels and LVEDD were higher in the HF group than those in the control group,while LVEF was lower than that in the control group(P<0.05).TRPC1,NT-pro BNP levels and LVEF,LVEDD were significantly different in patients with different cardiac functional grade(P<0.05).With the increase of cardiac function,TRPC1,NT-pro BNP levels and LVEDD increased,while LVEF decreased.TRPC1 level was positively correlated with NT-pro BNP and LVEDD(P<0.05),and it was negatively correlated with LVEF(P<0.05).TRPC1,NT-pro BNP,LVEF and LVEDD were all the risk factors for HF death(P<0.05).Conclusion TRPC1 is elevated in patients with HF,which is the risk factor for HF death.