基于网络药理学的小半夏汤治疗化疗性恶心呕吐的成分与作用机制研究

Compounds and Mechanism of Xiaobanxia Decoction in Treating Chemotheraphy-Induced Nausea and Vomiting Based on Network Pharmacology

目的通过网络药理学方法筛选小半夏汤治疗化疗性呕吐(chemotheraphy-induced nausea and vomiting,CINV)的活性成分,预测作用靶点,探讨其治疗CINV作用机制。方法通过中药系统药理学数据库等平台筛选小半夏汤的生物活性成分,利用CTD和OMIM数据库建立与恶心呕吐相关疾病靶点,从而构建小半夏汤有效药物-靶点-疾病网络,并用STRING数据库和DAVID数据库进行生物过程和信号通路分析。结果从数据库筛选出与治疗CINV有关的小半夏汤活性成分6种,作用于19个核心靶点,27条信号通路。显示小半夏汤治疗CINV主要与调控细胞凋亡、调节炎性反应应答及胃肠道黏膜修复、减轻胃肠道平滑肌痉挛等生物过程和信号通路有关。结论小半夏汤对CINV的治疗作用体现了中药多成分-多靶点-多途径的特点,为进一步探究小半夏汤治疗CINV机制提供实验研究依据和思路。

Objective To predict the active components and the mechanism of Xiaobanxia Decoction in the treatment of chemotherapy-induced vomiting by computer network pharmacology. The active ingredients of Xiaobanxia Decoction for the treatment of chemotherapy-induced nausea and vomiting(CINV) were screened by network pharmacological methods, and the target were predicted, The mechanism of CINV treatment was explored. Methods The bioactive ingredients of Xiaobanxia Decoction screened through platforms such as the Chinese Medicine System Pharmacology Database. CTD and OMIM databases were used to establish targets for diseases related to nausea and vomiting, and build an effective drug-target-disease network of Xiaobanxia Decoction, STRING database and DAVID Database were used for biological process and signal pathway analysis. Results A total of6 active ingredients of Xiaobanxia Decoction related to the treatment of CINV were screened out from the database, which acted on19 core targets and 27 signal pathways. It showed that Xiaobanxia Decoction’s treatment of CINV is mainly related to biological processes and signal pathways such as regulating apoptosis, regulating inflammatory response, repairing gastrointestinal mucosa, and reducing gastrointestinal smooth muscle spasm etc. Conclusion The therapeutic effects of Xiaobanxia Decoction on CINV reflects the characteristics of traditional Chinese medicine with multiple components, multiple targets, and multiple pathways, providing experimental research basis and ideas for further exploring the mechanism of Xiaobanxia Decoction in treating CINV.