ALDH1和PLK4蛋白表达水平变化与卵巢肿瘤良恶性的关系

The relationship between the expression of ALDH1 and PLK4 protein and benign and malignant ovarian tumors

探讨乙醛脱氢酶(ALDH1)、Polo样蛋白激酶4(PLK4)的表达与卵巢良恶性肿瘤的关系。收集本院经病理学检查确诊的卵巢癌组织和卵巢良性肿瘤组织标本,采用免疫组化检测技术分析两种标本中的ALDH1和PLK4蛋白表达水平,并分析卵巢癌不同FIGO分期、不同病理类型、不同分化程度、淋巴结转移与ALDH1和PLK4蛋白表达有关。结果显示,与良性组卵巢肿瘤组织相比,卵巢癌组织中的ALDH1和PLK4蛋白阳性表达率显著增高;卵巢癌组织中的ALDH1和PLK4蛋白在不同FIGO分期、不同的组织分化程度和淋巴结转移组织中的表达有显著差异(P<0.05)。结果提示,ALDH1和PLK4蛋白在卵巢癌组织中高表达,并与肿瘤的恶性度有关。

To investigate the relationship between the expression of aldehyde dehydrogenase(ALDH1)and Polo-like protein kinase 4(PLK4)and benign malignant ovarian tumors,the specimens of ovarian cancer and benign ovarian tumors were collected in our hospital.The expression levels of ALDH1 and PLK4 were analyzed by immunohistochemical technique.The relationship between the expression levels of ALDH1 and PLK4 in ovarian cancer and different FIGO stages,pathological types,differentiation degree and lymph node metastasis were also analyzed.Results showed,compared to benign malignant ovarian tumors,the positive expression rates of ALDH 1 and PLK4 proteins in ovarian cancer tissues were higher.There are significant difference between ALDH 1 and PLK4 protein in ovarian cancer tissues and FIGO stages,tissue differentiation degrees and lymph node metastasis.Results suggest that the expressions of ALDH1 and PLK4 in ovarian cancer tissues was higher,and related to malignant of ovarian tumors.