糖尿病性骨质疏松的研究进展

Research progress of diabetic osteoporosis

糖尿病性骨质疏松(diabetic osteoporosis,DOP)是糖尿病在人体骨系统中引起的严重慢性并发症,随着糖尿病患者群体的不断扩大,DOP发病率逐年升高,给社会和患者家庭带来巨大的经济负担。DOP发病机制复杂,早期无症状且受目前诊疗方案的限制从而导致患者知晓率低而致残率高。糖尿病患者血糖高、胰岛素样生长因子和胰岛素的缺乏是导致糖尿病性骨质疏松的重要原因,当前对DOP的治疗以降血糖药物联合抗骨质疏松药物为主,控制饮食和加强体育锻炼可以有效预防DOP。

Diabetes-induced osteoporosis(DOP) is a serious chronic complication of diabetes in bone system.The morbidity of DOP is increasing with the continues expansion of diabetic,which caused a huge economic burden to the society.As all known,the pathogenesis of DOP is complicated so that the diagnosis and treatment of disease are limited.The low awareness rate and high disability rate coexist in that the osteoporosis is asymptomatic in the early stage.High blood glucose,insulin-like growth factor,and insulin lack in diabetic patients are meaningful sources of diabetic osteoporosis.The current treatment of DOP depends on hypoglycemic drugs combined with anti-osteoporotic drugs.Controlling diet and enhancing physical exercise could definitely prevent DOP.