体质量对6～17岁儿童肺功能的影响

The effect of body weight on lung function in children aged 6-17 years

目的探讨体质量对儿童肺通气功能的影响.方法参考世界卫生组织儿童超重肥胖标准,在无呼吸道疾患或合并其他影响肺功能疾病的儿童中筛选出的肥胖、超重和正常体质量儿童进行肺通气功能测定,并进行比较.结果共纳入1233例儿童,其中肥胖儿童285例、超重儿童155例、正常体质量儿童793例.三组间肺容量指标VCMAX和FVC的差异有统计学意义(P<0.01),均以超重组为最高.三组间FEV1/VCMAX、FEV1/FVC、FEF75和MMEF25-75的差异均有统计学意义(P<0.01),均以对照组最高.肺组织通气指标FEV1和PEF以及FEF25和FEF50在三组间的差异无统计学意义(P>0.05).各组肺功能的实测值与前述结果类似,但改变程度则有所减轻.结论超重和肥胖儿童的肺容量较正常体质量儿童增加,同时会出现阻塞性病变和小气道功能障碍.

Objective To investigate the effect of body weight on pulmonary function in children.Method According to the World Health Organization's overweight and obesity standard for children,the obese,overweight and normal weight children were selected and grouped from children with neither respiratory disease nor other diseases affecting pulmonary function.Their pulmonary ventilation function were measured and compared.Results A total of 1233 children were included,including 285 obese children,155 overweight children and 793 normal weight children.There were significant differences in VCMAX and FVC among the three groups(P<0.01),and they were the highest in the overweight group.The differences of FEV1/VCMAX,FEV1/FVC,FEF75 and MMEF25-75 among the three groups were statistically significant(P<0.01)and they were the highest in the control group.There was no significant difference among the three groups in lung ventilation indexes of FEV1,PEF,FEF25 and FEF50(P>0.05).The actual values of lung function were similar to the ones above among the three groups but the degree of changes were smaller to some extent.Conclusions Overweight and obese children have increased lung capacity compared to the children with normal weight,and they may also have obstructive disease and small airway dysfunction.