肥大细胞在肠易激综合征中的作用研究进展

Research progress on role of mast cells in irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是一种多因素相互作用的胃肠道功能紊乱性疾病,全球范围内发病率较高。其发病机制复杂,如内脏高敏感、胃肠道动力异常、肠道屏障损坏、肠道免疫紊乱、神经免疫失调等。研究表明,肥大细胞(mast cells,MCs)在IBS的发生与发展中起到重要作用,在IBS治疗中也有初步尝试。该文就MCs在IBS发病机制中的作用及针对MCs的IBS治疗方案进行综述。

Irritable bowel syndrome(IBS)is one kind of functional gastrointestinal tract disorders with high incidence in the world.IBS is induced by avariety of factors,such as visceral hypersensitivity,abnormal gastrointestinal motility,intestinal barrier dysfunction,intestinal inflammation,neuro-immunity disorder,etc.The pathogenesis of IBS is complex and diverse.Mast cells(MCs)play an important role in the occurrence and development of IBS.The present article reviews the role of MCs both in the pathogenesis and in the treatment of IBS.