TRPM7通道在肿瘤发生发展过程中的作用研究进展

Research progress of TRPM7 channel and tumor development

瞬时电位受体(transient receptor potential,TRP)melastatin亚家族7(TRPM7)是一种包含功能性激酶结构域的非选择性阳离子通道。研究表明,多种肿瘤细胞中TRPM7异常高表达,可通过诱导细胞周期紊乱、调节细胞内阳离子浓度,促进肿瘤细胞生存与增殖。此外,TRPM7表达升高与肿瘤侵袭、转移能力的增加密切相关,且这种作用可能是通过促进上皮细胞-间充质转化及肿瘤血管生成产生的。TRPM7在肿瘤发生发展中的作用,使其成为恶性肿瘤的预后指标和潜在治疗靶点。该文对TRPM7与肿瘤进程的研究进展进行综述,探讨TRPM7介导肿瘤发展的机制及靶向TRPM7的临床治疗肿瘤策略,为后续研究和临床治疗提供一定参考。

Transient receptor potential melastatin-subfamily member 7(TRPM7)is a non-selective cation channel fused with a functional kinase domain.Studies have shown that TRPM7 is aberrantly expressed in tumor cells.TRPM7 plays a variety of functional roles in cancer cells including survival,cell cycle progression,proliferation,invasion,epithelial-mesenchymal transition(EMT)and angiogenesis.The high correlation between TRPM7 and tumorigenesis makes TRPM7 a prognostic indicator and a potential therapeutic target for malignant tumors.In this article,we review the research progress of TRPM7 and tumor progression,explore the mechanism of TRPM7-mediated tumor development and the clinical treatment of tumor strategy targeting TRPM7,and provide some reference for follow-up research and clinical treatment.