一种合成(R)-4-丙基-二氢呋喃-2-酮的新方法

An New Method of Synthesis of (R)-4-Propyl-Dihydro-Furan-2-One

本文介绍另一种合成(R)-4-丙基-二氢呋喃-2-酮的新方法。以正戊酸为起始原料,经酰化、不对称烷基化、还原关环等一系列反应合成(R)-4-丙基-二氢呋喃-2-酮。与目前的公开合成路线相比,反应步骤仅3步,且反应物A可高收率回收,成本显著降低;中间体C经重结晶,光学纯度高。本合成路线成本低廉,操作性强,可稳定地获得光学纯度高的目标产物。

An New method of synthesis of(R)-4-Propyl-Dihydro-Furan-2-One was reported in the paper.Taking Pentanoic acid as starting material,(R)-4-Propyl-Dihydro-Furan-2-One was synthesized by acylation,asymmetry alkylation,reduct-cyclization.Compared to reported method,this compound was syntheizde in only 3 steps with high optical purity and low cost,which the asymmetric oxazolidone reagent can be recovered in high yield,and the intermediate C was high optical purity after recrystallization.