抗肿瘤靶点研究及治疗策略

Study on Anti-tumor Targets and Associated Therapeutics

抗肿瘤靶向治疗(“targeted”cancer therapies)是在特异性靶向工具的引导下,小分子药物或抗体自身对肿瘤细胞及其微环境的攻击或激活机体免疫反应。靶向治疗的飞速发展使特异性抗肿瘤治疗得以实现,朝着治疗肿瘤的终极目标“有效杀伤肿瘤且不伤害正常组织”又迈进了一大步。本文就肿瘤靶向治疗的相关内容,肿瘤相关抗原、抗体、靶向策略等近年来的发展进程进行回顾,并结合本团队的研究内容对该领域的研究做详细的阐述。

Anti-cancer targeted therapy(“targeted”cancer therapy)is the use of small molecule drugs or antibodies themselves,guided by specific targeting tools,to attack tumor cells and their microenvironment or activate the body s im mune response.The rapid development of targeted therapy has enabled specific anti-tumor therapies to be achieved,which has taken us another step closer to our ultimate goal of treating tumors,that is,to effectively kill tumors without harming normal tissues.This article reviews the related contents of tumor targeted therapy,such as tumor-associated anti gens,antibodies,and targeting strategies,and also elaborates on the research in this field in combination with the study of our team.