浸润性乳腺癌中FosB的表达与超声征象及临床病理的相关性

Relation among Ultrasound Findings,Clinical Significance and Expression of FosB in Invasive Breast Cancer

[目的]分析FosB在浸润性乳腺癌中的表达及临床病理意义,并探讨其与超声征象的相关性。[方法]收集155例浸润性乳腺癌组织、36乳腺癌旁组织及30例正常乳腺组织做为对照,均采用免疫组织化学SP法和超声检测,分析FosB在浸润性乳腺癌中的的表达差异与组织学分级、淋巴结转移、超声征象等的关系。[结果]①FosB在癌旁组织及正常乳腺组织中的表达水平明显高于浸润性乳腺癌组织中的表达(P<0.01)。②FosB在浸润性乳腺癌组织中的高表达与低组织学分级、ER阳性及PR阳性相关(P<0.05),与肿物直径大小、年龄、淋巴结转移、Her2及临床分期无关(P>0.05)。③FosB在存在微钙化或腋窝淋巴结增大的浸润性乳腺癌组织中高表达,差异有统计学意义(P<0.05);而在不同肿块大小、纵横比、形态、边界、后方回声衰减及彩色血流之间无统计学差异(P>0.05)。[结论]F osB在乳腺癌组织中的表达水平明显低于癌旁组织及正常乳腺组织,其差异表达与组织学分级、ER、PR相关,有助于乳腺癌的鉴别诊断和指导ER/PR相关患者的个性化治疗。FosB在乳腺癌组织中的差异表达还与微钙化、腋窝淋巴结存在一定的相关性,联合超声与FosB能够更加明确的判读浸润性乳腺癌的恶性程度。

【Objective】To investigate the expression of FosB in invasive breast cancer and its correlation to the ultra⁃sound findings and clinical significance.【Methods】Immunohistochemical and ultrasound examination were performed for 155 cases with invasive breast cancer,36 cases with paracancerous tissue and 30 cases with normal breast tissue.To in⁃vestigate the correlations between the different expression of FosB with histological grade,lymph nodes,and ultrasound findings.【Results】①The expression of FosB in paracancerous tissue and normal breast tissue was higher than that in in⁃vasive breast cancer(P<0.01).②Based on immunohistochemical staining,high positive expression rate of FosB was as⁃sociated with low histological grade,ER positive and PR positive(P<0.05).There was no correlation between FosB and age,tumor diameter,lymph nodes,Her2 and clinical stages(P>0.05)③The expression of FosB was higher in micro⁃calcification positive and lymph nodes bigger tissues(P<0.05).There was no correlation between FosB and tumor size,regular shape,boundary,posterior attenuation ratio and blood flow(P>0.05).【Conclusion】The expression of FosB in invasive breast cancer was lower than that in paracancerous tissue and normal breast tissue.The different expression of FosB was correlated with histological grade,ER positive and PR positive.To study the expression of FosB in invasive breast cancer may be helpful for differential diagnosis and targeted treatment.The different expression of FosB was corre⁃lated with microcalcification,lymph nodes,and combined FosB with ultrasound findings may contribute to prognostic eval⁃uation of breast cancer.