常见自身抗体在自身免疫性疾病中的研究进展

Advances in the study of common autoantibodies in autoimmune diseases

全球自身免疫性疾病的发病率和患病率都呈逐年上升状态,自身抗体的检测对免疫性疾病的诊断具有重要参考意义。人体的生长、发育受完整的自身免疫耐受机制的影响,正常的免疫反应起着保护及防御的作用,一旦自身耐受机制的完整性受到破坏,就会促使自身免疫反应的发生,从而产生自身抗体。通过研究各地相关实验室数据来了解目前自身抗体的研究进展,进一步为医务人员明确自身免疫性疾病的诊断、治疗以及评估预后提供指导意见。此外,还可以利用自身抗体的区域流行病学分布来阐明不同区域和人群中疾病梯度的决定因素。在过去的几十年中,我国在自身免疫性疾病机制的研究方面取得了巨大成就,因此,对自身抗体的研究可以为相关自身免疫性疾病的诊治提供新的见解,也为新型疗法的发展提供启示,未来可以以此为方向进一步指导治疗。因此本文就常见自身抗体在自身免疫性疾病中的研究进展展开探讨。

The incidence and prevalence of autoimmune diseases are increasing year by year all over the world.The growth and development of human body are affected by the complete autoimmune tolerance mechanism,and the normal immune response plays the role of protection and defense.Once the integrity of the tolerance mechanism is destroyed,it will promote the occurrence of autoimmune response,thus producing autoantibodies.By studying the data of relevant laboratories in different regions,we can understand the current research progress of autoantibodies,and provide guidance for medical staff to determine the diagnosis,treatment and prognosis of autoimmune diseases.In addition,the regional epidemiological distribution of autoantibodies can be used to elucidate the determinants of disease gradients in different regions and populations.In the past few decades,great achievements have been made in the research on the mechanism of autoimmune diseases in China.Therefore,the research on autoantibodies can provide new insights for the diagnosis and treatment of autoimmune diseases and provide enlightenment for the development of new therapies,which can further guide the treatment in the future.This paper discusses the research progress of common autoantibodies in autoimmune diseases.