IGF2-AS与肿瘤关系的研究进展

Research progress on the relationship between IGF2-AS and tumor

IGF2-AS是一种新发现的癌症相关lncRNA,是IGF2的反义长链非编码RNA,在多种肿瘤中均有差异性表达。许多研究发现,IGF2-AS在肿瘤的形成中具有潜在的促癌或抑癌作用,并通过调节多种基因表达及信号通路参与肿瘤的发生、发展过程。因此,研究IGF2-AS与肿瘤的关系,在肿瘤的早期诊断、预后评价及指导临床治疗等方面可能有着重要意义。

The insulin-like growth factor antisense gene(IGF2-AS)is a newly discovered cancer-related lncRNA,which is the antisense long-chain non-coding RNA of IGF2 and is differentially expressed in various tumors.Many studies have found that IGF2-AS plays a potential role in promoting or inhibiting cancer in the formation of tumors,which participates in the occurrence and development of tumors by regulating various gene expressions and signaling pathways.Therefore,the study on the relationship between IGF2-AS and tumor may be of great significance in the early diagnosis,prognosis evaluation and clinical treatment guidance of tumor.