中药调节肠道菌群在溃疡性结肠炎治疗中的应用概述

Overview of Treatment of Ulcerative Colitis by Regulating Intestinal Flora with Chinese Materia Medica

有研究表明,肠道微生态失衡是导致溃疡性结肠炎的一个重要因素。笔者从肠道微生态角度出发,对近年来关于中药单体、活性成分、复方及制剂调节肠道菌群、治疗溃疡性结肠炎的实验与临床研究进行总结。发现中药治疗溃疡性结肠炎疗效好,不良反应少,能有效减少病情复发;无论是单味中药及其活性成分,还是中药复方均能有效调节肠道益生菌、减少有害菌群数量,使肠道菌群恢复平衡状态,从而间接调节肠道黏膜免疫功能,促进结直肠黏膜的修复。但中药通过调节肠道菌群治疗溃疡性结肠炎的疗效目前尚缺乏循证医学证据,今后应加强相关中药药理作用研究,为中药调节肠道菌群在溃疡性结肠炎治疗中的应用提供更加有力的证据。参考文献35篇。

There are studies showing that the imbalance of intestinal microecology is an important factor for the pathogenesis of ulcerative colitis.Therefore,from the perspective of intestinal microecology,this article summarizes the experimental and clinical studies on the treatment of ulcerative colitis by regulating intestinal flora with monomer,active ingredients and compound prescriptions of Chinese materia medica in recent years.It is found that the treatment of ulcerative colitis with Chinese materia medica has good curative effect,few adverse reactions and effective reduction of relapse.Either one of the above three methods(single Chinese materia medica,active ingredients of Chinese materia medica and compound Chinese materia medica)can effectively regulate intestinal probiotics,reduce the number of harmful bacteria,restore the balance of intestinal flora,and indirectly regulate the recovery of intestinal mucosal immune function and help the repair of colorectal mucosa.However,the curative efficacy of Chinese materia medica on ulcerative colitis related to regulating intestinal probiotics is not evidence-based.Therefore,studies on the pharmacological effects of Chinese materia medica should be strengthened in the future to provide more powerful evidence for the application of Chinese materia medica in the treatment of ulcerative colitis.There are 35 references.