膜联蛋白A1、sd-LDL、Angptl2与冠心病及对冠状动脉粥样硬化病变程度的诊断价值

The relationship between annexin A1,sd-LDL,Angptl2 and the severity of coronary heart disease and its diagnostic value for severe coronary atherosclerosis

目的探讨膜联蛋白A1(AnxA1)、小而密低密度脂蛋白(sd-LDL)、血管生成素样蛋白2(Angptl2)与冠心病(CHD)病变程度的关系及对冠状动脉粥样硬化严重病变的诊断价值。方法选取本院2017年8月至2019年8月102例CHD患者作为研究对象。比较不同临床特征患者血清AnxA1、sd-LDL、Angptl2水平,Pearson相关性分析各血清因子与Gensini评分、冠状动脉病变支数相关性,应用受试者工作特征(ROC)曲线分析血清AnxA1、sd-LDL、Angptl2对冠状动脉粥样硬化严重病变的诊断价值。结果不同疾病类型、Gensini评分、冠状动脉病变支数患者血清AnxA1、sd-LDL、Angptl2水平存在显著差异,有统计学意义(P<0.05);血清AnxA1、sd-LDL、Angptl2与Gensini评分呈正相关(P<0.05);血清AnxA1、sd-LDL、Angptl2与冠状动脉病变支数呈正相关,差异有统计学意义(P<0.05);血清AnxA1诊断冠状动脉粥样硬化严重病变的Roc曲线下的面积(AUC)值为0.791,大于血清sd-LDL、Angptl2;血清AnxA1、sd-LDL、Angptl2联合诊断冠状动脉粥样硬化严重病变的AUC值为0.895。结论CHD患者存在血清AnxA1、sd-LDL、Angptl2异常表达情况,且与冠脉病变严重程度关系密切,3者联合检测在CHD患者冠脉严重病变诊断中价值最高,可为临床诊断、完善治疗方案提供数据参考。

Objective To investigate the relationship between annexin A1(AnxA1),small and dense low⁃density lipoprotein(sd⁃LDL),angiopoietin⁃like protein 2(Angptl2),and the degree of coronary heart disease(CHD)lesions,and to coronary atherosclerosis diagnostic value of severe sclerosis.Methods A total of 102 patients with CHD in our hospital from August 2017 to August 2019 were selected as the research subjects.Compare the serum levels of AnxA1,sd⁃LDL,and Angptl2 in patients with different clinical characteristics,and analyze the correlation between each serum factor and the Gensini score and the number of coronary lesions by Pearson correlation analysis,the receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum AnxA1,sd⁃LDL,and Angptl2 for severe coronary atherosclerosis.Results The serum levels of AnxA1,sd⁃LDL,and Angptl2 in patients with different disease types,Gensini scores,and number of coronary artery lesions were significantly different(P<0.05).Serum AnxA1,sd⁃LDL,and Angptl2 were positively correlated with Gensini scores(P<0.05).Serum AnxA1,sd⁃LDL,and Angptl2 were positively correlated with the number of coronary artery lesions,and the difference was statistically significant(P<0.05).The AUC value of serum AnxA1 in the diagnosis of severe coronary atherosclerosis was 0.791,which was greater than that of serum sd⁃LDL and Angptl2.The AUC value of serum AnxA1,sd⁃LDL and Angptl2 in the diagnosis of severe coronary atherosclerosis was 0.895.Conclusion CHD patients have abnormal expressions of serum AnxA1,sd⁃LDL,and Angptl2,and are closely related to the severity of coronary lesions.The combined detection of the three has the highest value in the diagnosis of severe coronary lesions in CHD patients,which can provide clinical diagnosis and improve the treatment plan data reference.