摘要
BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODS We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors.The levels of serum PG I/PG II and IgG against H.pylori were measured.According to their serological status,the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients,63(81.8%)expressed KK-LC-1.The IgG titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/H.pylori infection(+)]was as high as 93.9%high.KK-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H.pylori infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC.
BACKGROUND The ABCD stratification [(combination of serum pepsinogen(PG) levels and titers of antibody(immunoglobulin G, Ig G) against Helicobacter pylori(H. pylori)] is effective for the classification of individuals at risk of developing gastric cancer(GC). The Kita–Kyushu lung cancer antigen-1(KK-LC-1) is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODSWe analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors. The levels of serum PG I/PG II and Ig G against H. pylori were measured. According to their serological status, the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients, 63(81.8%) expressed KK-LC-1. The Ig G titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P = 0.0289 and P = 0.0041,respectively). The expression of KK-LC-1 in group C [PG method(+)/H. pylori infection(+)] was as high as 93.9% high. KK-LC-1 was also detected in group A [-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H. pylori infection and atrophic status, so that, KK-LC-1 may be a useful marker for the diagnosis of GC.
基金
Supported by Grant-in-Aid for research by the Kitasato University Medical Center,No.H26-008
the JSPS KAKENHI,No.17K16578
the JSPS KAKENHI,No.26670609
Takeda Science Foundation
Kitasato University Research Grant for Young Researchers
Grant-in-Aid for research from the Kitasato University Medical Center,No.H25-0006
