PPAR_γ激动剂荧光探针法研究进展

Progress in Fluorescent Probes for PPAR Gamma Agonists

过氧化物酶增殖激活受体(peroxisome proliferatoractivated receptors,PPARs)属于核激素受体家族中的配体激活受体,包括3种亚型:PPARα、PPARβ/δ和PPARγ。PPARγ具有增强机体对胰岛素敏感性,调节体内糖平衡以及脂肪分化、生成等多种生物学功能。通过荧光探针法研究PPARγ与配体结合,对研究PPARγ激动剂作用机制及筛选PPARγ激动剂具有重要的意义。本文针对新型荧光探针法探究PPARγ与配体的结合能力以及筛选PPARγ激动剂研究进行综述。

Peroxisome proliferator activated receptors(PPARs)are ligand-activated receptors in the nuclear hormone receptor family,including three subtypes:PPARα,PPARβ/δand PPARγ.PPARγhas many biological functions,such as enhancing insulin sensitivity,regulating sugar balance,adipose differentiation and formation.The study of PPARγbinding to ligand by fluorescent probe method has great significance for studying the mechanism of PPARγagonist and screening PPARγagonists.This review summarizes the novel fluorescent probe method to explore the binding ability of PPARγto ligands and the screening of PPARγagonists.