摘要
流行病学研究表明,绝经后女性阿尔茨海默病(Alzheimer’s disease,AD)的患病风险远高于男性。大量临床实验研究表明,女性绝经后脑源雌激素水平的下降与阿尔茨海默病的患病风险有关。该文介绍了近年来关于体内雌激素(尤其脑源雌激素)合成及代谢过程和作用机制、脑雌激素受体(estrogen receptors,ERs)、脑源雌激素在调节认知功能中的作用以及脑源雌激素功能异常在AD中的作用的研究进展。
Epidemiological studies have shown that the risk of Alzheimer’s disease(AD)in postmenopausal women is much higher than that in men. Numerous clinical trials have indicated that decreased level of brain-derived estrogen in women is related to the risk of AD. This review focuses on the synthesis,metabolism and action mechanisms of estrogen(especially brain-derived estrogen),the role of brain estrogen receptors(ERs),brain-derived estrogen in the regulation of cognitive function and brain-derived estrogen dysfunction in the progression of AD.
作者
杨琳
艾静
YANG-Lin;AI-Jing(Department of Pharmacology,Harbin Medical University,Harbin,150086,China)
出处
《神经药理学报》
2019年第5期50-64,共15页
Acta Neuropharmacologica
基金
国家自然科学基金资助项目(No.81671052、No.81870849、No.81471115)
黑龙江省自然基金重点项目(No.ZD2018004)
关键词
阿尔茨海默病
脑源雌激素
雌激素受体
Alzheimer’s disease
brain-derived estrogen
estrogen receptors
