摘要
IgA肾病的发生与自身免疫相关,其特征为肾小球系膜区IgA沉积。IgA肾病的发病机制尚不清楚,但现已证实补体异常活化在IgA肾病发生发展中起重要作用,参与IgA肾病发生发展过程的主要为补体替代途径和凝集素途径。本文就补体系统在IgA肾病发生发展中的作用进行了综述。
IgA nephropathy is considered as an autoimmune disease,and characterized by the deposition of IgA in the mesangium of glomeruli.The pathogenesis of IgA nephropathy is not clear,but it has been confirmed that the complement system abnormally activated plays a critical role in the development of IgA nephropathy.Recent studies indicated that the complement activation in IgA nephropathy is mainly via the alternative pathway and lectin pathway.In this review,the contribution of the complement system to the IgA nephropathy was summarized.
作者
张岩
段姝伟
蔡广研
陈香美
Zhang Yan;Duan Shuwei;Cai Guangyan;Chen Xiangmei(Department of Nephrology,Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Nephrology,Beijing 100853,China)
出处
《中华肾病研究电子杂志》
2019年第6期269-272,共4页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
基金
北京市科委IgA肾病项目(D181100000118002)
关键词
IGA肾病
补体系统
替代途径
凝集素途径
IgA nephropathy
Complement system
Alternative pathway
Lectin pathway
