肠道微生物与性激素相关疾病研究进展

Research Progress on Intestinal Microbe and Sex Hormone Related Diseases

数以万亿计的微生物生活在人类肠道中,形成了一个复杂的微生态群落。肠道微生物可为宿主提供营养和能量,并与人类疾病的发生发展密切相关。随着研究的不断深入,越来越多的证据表明肠道微生物的改变可引起性激素水平变化,进而导致一系列相关的疾病发生。本文就肠道微生物与多囊卵巢综合征、乳腺癌、卵巢癌等性激素相关疾病之间的关系进行阐述,旨在为人类疾病诊疗提供新思路。

Trillions of microbes inhabit the human intestine,forming a complex microecological community. It is clear that intestinal microorganisms provide nutrients and energy to the host and are involved in the occurrence and development of human diseases. With the deepening of relevant researches,growingly evidences indicate that changes in intestinal microorganisms cause variations in sex hormone levels,thus leading to a series of related diseases. In this review,we discuss the relationships between intestinal microorganisms and sex hormone-related diseases such as polycystic ovary syndrome,breast cancer and ovarian cancer,etc.,aiming to provide new ideas for the diagnosis and treatment of human diseases.