期刊文献+

妊娠期高血压疾病相关因素分析 被引量:26

Analysis on factors related to hypertensive disorder complicating pregnancy
下载PDF
导出
摘要 目的探讨淋巴细胞/单核细胞数的比值(LMR)与妊娠期高血压疾病(HDCP)的相关性。方法选择2013年1月至2017年12月在该院产前检查或住院治疗诊断为HDCP的患者366例(病例组),选取同期在该院分娩的无并发症及合并症的孕产妇692例为对照组,收集两组对象与HDCP相关的产前检查常用指标及LMR、WBC、中性粒细胞百分比(NEUT%)3个炎症相关指标,将有差异的指标与HDCP进行相关性分析,并评估LMR与HDCP的相关性。结果病例组与对照组单核细胞数及孕期增加体质量比较,差异无统计学意义(P>0.05);两组对象的年龄、羊水指数(AFI)、尿蛋白、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆汁酸、肌酐、分娩时体质量指数(BMI)、血压、新生儿体质量、Apgar评分、WBC、NEUT%、LMR、淋巴细胞数比较,差异均有统计学意义(P<0.05)。二元Logistic回归结果显示尿蛋白、肌酐、血压、NEUT%、LMR与HDCP的发生存在一定的正相关关系(B>0,P<0.05)。多项Logistic回归结果显示血压、尿蛋白、NEUT%、LMR与HDCP严重程度相关(B>0,P<0.05)。结论HDCP患者LMR高于正常孕妇,且随着疾病的严重程度增加而增加。LMR高于3.95需警惕HDCP的发生。 Objective To study the correlation between lymphocytes/monocytes ratio(LMR)and hypertensive disorder complicating pregnancy(HDCP).Methods A total of 366 patients with prenatal examination or hospitalization diagnosed as HDCP in this hospital from January 2013 to December 2017 were selected as the case group and contemporaneous 692 pregnant parturients with delivery in this hospital without complications and concomitant diseases were selected as the control group.The HDCP related prenatal examination common indexes and 3 inflammation related indexes of LMR,WBC count,neutrophilic granulocyte percentage(NEUT%)were collected.The different indexes and HDCP conducted the correlation analysis.The correlation between LMR and HDCP was evaluated.Results The monocytes number and increased BMI during pregnancy had no statistical difference between the case group and control group(P>0.05);the age,amniotic fluid index(AFI),urine protein,ALT,AST,total bile acid,creatinine,BMI at delivery,blood pressure,new born body mass,Apgar score,WBC count,NEUT%,LMR and lymphocytes had statistical differences between the two groups(P<0.05).The binary Logistic regression results showed that urine protein,creatinine,blood pressure,NEUT%and LMR had a certain positive correlation with the HDCP occurrence(B>0,P<0.05).The multiterm Logistic regression results showed that blood pressure,urine protein,NEUT%and LMR were correlated with the HDCP severity(B>0,P<0.05).Conclusion LMR in HDCP patients is higher than that in the normal pregnant women,moreover the LMR value is increased with the disease severity increase.LMR higher than 3.95 needs to be alert to the HDCP occurrence.
作者 石晛 邓芯茹 钟小翠 张琦 董晓静 SHI Xian;DENG Xinru;ZHONG Xiaocui;ZHANG Qi;DONG Xiaojing(Department of Gynecology and Obstetrics,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处 《重庆医学》 CAS 2020年第3期457-462,共6页 Chongqing medicine
关键词 高血压 妊娠性 淋巴细胞/单核细胞数的比值 相关性分析 hypertension pregnancy-induced lymphocyte/monocyte ratio correlation analysis
  • 相关文献

二级参考文献18

  • 1American College of Obstetricians and Gynecologists, Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy [J]. Obstet Gynecol, 2013, 122(5): 1122-1131.
  • 2Lowe SA, Brown MA, Dekker GA, et al. Guidelines for the management of hypertensive disorders of pregnancy 2008[J]. Aust N Z J Obstet Gynaecol, 2009, 49(3):242-246.
  • 3Lowe SA, Bowyer L, Lust K, et al. The SOMANZ GuideLines for the Management of Hypertensive Disorders of Pregnancy 2014[J].Aust N Z J Obstet Gynaecol, 2015, 55(1):11-16.
  • 4Magee LA, Helewa M, Moutquin JM, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy[J]. J Obstet Gynaecol Can, 2008, 30(Snppl):S 1-48.
  • 5Magee LA, Pels A, Helewa M, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summm'y[J]. J Obstet Gynaeeol Can, 2014, 36(5): 416-441.
  • 6Schiff E, Friedman SA, Kao L, et al. The importance of urinary protein excretion during conservative management of severe preeclampsia[J]. Am J Obstet Gynecol, 1996, 175(5): 1313-1316.
  • 7Buchbinder A, Sibai BM, Caritis S, et al. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia[J]. Am J Obstet Gynecol, 2002, 186(1):66-71.
  • 8Newman MG, Robichaux AG, Stedman CM, et al. Perinatal outcomes in preeclampsia that is complicated by massive proteinuria[J]. Am J Obstet Gynecol, 2003, 188(1 ):264-268.
  • 9Publications Committee, Society for Maternal-Fetal Medicine, Sibai BM. Evaluation and management of severe preeclampsia before 34 weeks' gestation[J]. Am J Obstet Gynecol, 2011,205(3): 191-198.
  • 10Thangaratinam S, Coomarasamy A, O' Mahony F, et al. Estimation of proteinuria as a predictor of complications of pre-eclampsia: a systematic review[J]. BMC Med, 2009, 7:10.

共引文献60

同被引文献286

引证文献26

二级引证文献88

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部