2型糖尿病患者行经尿道前列腺切除术后发生全身炎症反应综合征的危险因素分析

Risk factors of systemic inflammatory response syndrome in type 2 diabetic patients after transurethral resection of prostate

目的分析合并2型糖尿病的良性前列腺增生(BPH)患者行经尿道前列腺切除术(TURP)术后发生全身炎症反应综合征的危险因素。方法选取2014年1月—2019年5月石河子大学医学院第一附属医院和石河子市人民医院因BPH行TURP且术前诊断为2型糖尿病的患者101例为研究对象,分为SIRS组和No SIRS组,分别采用单因素分析及多因素Logistic回归分析对两组的年龄、前列腺质量、术前血糖水平、术前血红蛋白等因素进行统计学分析。结果术后39例(38.6%)患者发生SIRS,SIRS的发生与术前白细胞计数、手术时间、年龄、BMI及前列腺质量无显著相关性,而与术前血红蛋白水平(P=0.01)、术前血糖(P=0.000)显著相关性。结论术前高血糖可能是导致术后SIRS发生的重要影响因素,当术前血糖≥10 mmol/L时,SIRS的发生是血糖正常水平的26.552倍,血糖<10 mmol/L与术后SIRS的发生无明显相关性。此外,术前血红蛋白水平可能是术后发生SIRS的保护因素,在140~160 g/L时,术后发生SIRS的风险下降0.055倍。

Objective To analyze the risk factors of systemic inflammatory response syndrome(SIRS)in the patients with type 2 diabetes diagnosed and benign prostatic hyperplasia after transurethral resection of the prostate(TURP).Methods 101 patients with BPH and type 2 diabetes had done TURP were from the First Affiliated Hospital of Medical School of Shihezi University and shihezi people's hospital were divided into SIRS group and No SIRS group.The single factor analysis and multiple factors Logistic regression analysis were used to compare with the different between two groups of age,prostate gravity,preoperative blood sugar level quality,preoperative hemoglobin.Results 39(38.6%)patients occured SIRS after operation,and the occurrence rate of SIRS was not significantly correlated with the preoperative white blood cell count,operation time,age,BMI and prostate mass,but significantly correlated with the preoperative hemoglobin level(P<0.05)and preoperative blood glucose(P<0.01).Conclusion Preoperative blood glucose is an important factor leading to SIRS.When preoperative blood glucose was more than 10mmol/L,the occurrence rate of SIRS was 26.552 times than normal blood glucose level.Blood glucose was under 10mmol/L,there wasn't significant difference between the blood glucose and occurrence of postoperative SIRS.In addition,preoperative hemoglobin level had prevention of SIRS.At 140-160g/L,the risk of postoperative SIRS decreased by 0.055 times.