干细胞ECM修复软骨缺损与鹿茸干细胞ECM的研究进展

Research Progress of Stem Cell Extracellular Matrix in Repairing Cartilage Defects and Antler Stem Cell Extracellular Matrix

鹿茸软骨中富含血管,不但能修复缺陷还能实现再生,是研究软骨缺损修复的良好天然模型。由于鹿茸干细胞所分化的软骨分布着丰富的血管网络,所以其ECM中可能含有大量促进软骨生成的细胞因子和功能蛋白。本文就软骨缺陷修复进行综述,对使用鹿茸干细胞ECM修复软骨缺陷的初步结果进行总结,并提出展望。

Antler cartilage is rich in blood vessels, which can not only promote defect repair, but also regenerate itself,thus antler is a good animal model to use for the study of cartilage defect repair. Because the cartilage differentiated from antler stem cells is rich in vascular networks, its extracellular matrix(ECM) contains a large number of cytokines and functional proteins that can promote cartilage formation. In this paper, the currentstatus of repairing cartilage defects was reviewed, and the preliminary results of using antler stem cell ECM to repair cartilage defects were summarized, and the prospects were put forward.