核酸适配体在沙门氏菌快速检测中的研究进展

Research Progress of Aptamers in Rapid Detection of Salmonella

沙门氏菌是人畜共患病原菌,严重威胁人体健康。为有效控制沙门氏菌感染食品,预防因沙门氏菌感染而引起的食物中毒,对其进行快速检测很有必要。核酸适配体作为一种新型的仿生识别分子能特异性结合靶标物质,为食品安全快速检测技术的实现开辟了一条新的路径。此项技术具有靶分子范围广、稳定性好、制备及修饰方便等优点。通过介绍核酸适配体的概念、作用机理及特点,将核酸适配体在沙门氏菌的具体应用和发展方向作进一步的阐述。

Salmonella is a pathogen shared by human and animals,which is harmful to people's health.In order to effectively control the food infected by Salmonella and prevent the food poisoning caused by Salmonella infection,it is necessary to detect it quickly.As a new biomimetic recognition molecule,aptamer can specifically bind to the target substance,which opens up a new path for the realization of food safety rapid detection technology.This technology has the advantages of wide range of target molecules,good stability,convenient preparation and modification.In this paper,the concept,mechanism and characteristics of aptamers were introduced,and the specific application and development direction of aptamers in Salmonella were further elaborated.