膀胱癌患者TK1、DKK-1与生存关系分析

Analysis of Relationship between TK1, DKK-1 and Survival in Patients with Bladder Cancer

目的:观察探讨TK1、Dickkopf-1(DKK-1)对膀胱癌治疗、预后效果的临床应用价值,并对其与患者生存关系进行分析研究。方法:选择2014年1月-2015年1月吉林省一汽总医院泌尿外科收治的84例膀胱癌患者作为研究组,又选取同期84例健康志愿者作为对照组,对比两组TK1、DKK-1水平,分析其与患者生存的关系。结果:研究组TK1、DKK-1水平均明显高于对照组,研究组治疗干预后TK1、DKK-1水平均明显低于治疗干预前的水平(P<0.05);3年后患者的生存率为77.38%(65/84),成功生存者TK1、DKK-1水平均明显低于生存失败者(P<0.05),TK1、DKK-1水平与患者生存情况均存在负相关性(r=-0.154、-0.146,P<0.01)。结论:TK1、DKK-1在膀胱癌患者治疗前后水平差异显著,且TK1、DKK-1水平与患者生存情况均存在相关性,TK1、DKK-1水平越低,患者预后情况越好,可将其作为预测预后的指标。

Objective:To observe the clinical value of TK1,DKK-1 in the treatment and prognosis of patients with bladder cancer,and the relationship between it and the survival of patients was analyzed and studied.Method:From January 2014 to January 2015,84 patients with bladder cancer treated in the Department of Urology,Jilin FAW General Hospital were selected as the study group.84 healthy volunteers in the same period were selected as the control group.The TK1,DKK-1 levels of two groups were compared and the relationship between them and the survival of the patients was analyzed.Result:The levels of TK1,DKK-1 in the study group were significantly higher than those in the control group(P<0.05).The levels of TK1,DKK-1 in the study group after treatment intervention were significantly lower than those of before treatment intervention(P<0.05).The survival rate of patients after 3 years was 77.38%(65/84).The TK1,DKK-1 levels of patients with successful survival were significantly lower than those of patients with failure of survival(P<0.05).There was a negative correlation between the level of TK1 and DKK-1 and the survival of patients(r=-0.154,-0.146,P<0.01).Conclusion:There are significant differences in the level of TK1,DKK-1 before and after treatment,and the TK1 and DKK-1 levels are negatively correlated with patient survival,and the level of TK1 and DKK-1 are correlated with the survival of patients,it can be used as an index to predict the prognosis of patients.